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AIM:To observe the effect ofTongmai Liquid on endothelin(ET),interlenkin-18(IL-18),macrophage colony stimulating factor(M-CSF)in patients with coronary heart disease(CHD).METHODS:Eighty patients with coronary heart disease accompanied by heart and spleen qi deficiency and qi stagnanty+phlegm stasis and were randomly assigned into test group and control groups.Forty patients in test group were treated with Tongmai Liquid,30 mL,thrice per day,Forty patients in control group were treated with Shexiang Baoxin Pills,2 pills every time,thrice per day.The therapeutic course for both groups was 30 days.The blood-serum ET,IL-18 and M-CSF had been tested before and after the treatment.RESULTS:The levels of blood-serum ET,IL-18 and MCSF in the two groups decreased significantly after treatment(P＜0.05).There's significant difference in two groups'blood-serum of ET(P＜0.05),There're no significant diffference in two groups'blood-serum level IL-18 and of M-CSF(P＞0.05).CONCLUSION:Tongmai Liquid may decrease blood-serum level of ET,IL-18 and M-CSF in patients with coronary heart disease without side effect.
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Objective To study the effects of Tongxin Plaster on serum macrophage colony stimulating factor (M-CSF), homocysteine (HCY), and granules membrane protein-140 (GMP-140) of patients with angina pectoris of coronary heart disease. Methods Eighty CHD patients were randomly divided into two groups. Forty-one cases in treatment group were given acupoint application of Tongxin Plaster on acupoint Tanzhong (CV 17) and Xinshu (BL 15) 12 hours a day. Thirty-nine cases in control group were given orally Shexiangbaoxin Pill, 2 pills twice a day. The treatment course of the two groups was 3 weeks. The serum levels of M-CSF, HCY and GMP-140 were detected respectively. Results After treatment, the levels of M-CSF, HCY, GMP-140 in both groups were all decreased significantly (P 0.05). Conclusion Tongxin Plaster has good effects on antagonizing inflammatory response of coronary artery, inhibiting activation of platelets and degrading the level of homocysteine, which may be one of the mechanisms for Tongxin Plaster in treating CHD.
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Objective To observe the effect of Shuxuening Injection NO, NOS, SOD and MDA on of angina pectoris patients. Methods 100 patients with angina pectoris were randomly divided into two groups. 50 patients in treatment group were treated with Shuxuening Injection, 5 mL once, drop into 250 mL 5% glucose injection (it change into 250 mL 0.9% sodium chloride injection if the patient have diabetes), one time a day. 50 patients in control group were treated with isosorbide mononitrate injection, 60 mg once, drop into 250 mL 5% glucose injection (it change into 250 mL 0.9% sodium chloride injection if the patient have diabetes), 15 gtt one minute, one time a day. Results NO, NOS and SOD of the treatment group were objective improved, and MDA objective reduced. NO improved from (47.61?8.76)?mol/L to (71.84? 13.26)?mol/L, NOS improved from (1.64?0.23)U/mL to (2.31?0.29)U/mL, SOD improved from (46.34? 5.62)U/mL to (64.54?9.10)U/mL, and MDA reduced from (8.96?1.76)U/mL to (6.71?1.43)U/mL. Total effective rate in improving angina pectoris was 96%, and ECG was 76%. The time (ischemic ST-T changes) of holter ECG was reduced from (130.45?18.61)min to (32.33?5.32)min, there was a significant difference between the two groups (P